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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
4.55
Human Site:
S1222
Identified Species:
7.69
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
S1222
Q
H
K
K
K
L
R
S
P
Q
I
L
V
P
T
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
S1222
Q
H
K
K
K
L
R
S
P
Q
I
L
V
P
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
N1222
Q
H
K
K
K
L
K
N
P
Q
I
L
I
P
T
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
C1222
Q
H
K
K
K
L
K
C
P
Q
I
L
I
P
P
Rat
Rattus norvegicus
NP_001101888
2143
241191
C1222
Q
H
K
K
K
L
K
C
P
Q
I
L
I
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
R1233
Q
H
K
K
K
L
K
R
P
Q
A
L
V
P
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
R1217
Q
H
K
K
K
L
K
R
A
Q
Y
L
V
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
G1185
E
H
K
K
Q
L
V
G
A
E
L
L
I
P
P
Honey Bee
Apis mellifera
XP_393800
2028
231830
E1136
P
T
I
I
N
R
K
E
W
K
R
G
V
T
L
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
R811
A
I
D
I
P
A
H
R
R
A
R
I
A
Q
A
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
L796
R
V
A
G
T
V
Y
L
H
S
S
Q
V
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
R1137
G
A
K
E
A
V
L
R
L
K
L
S
S
S
T
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
R930
D
I
L
V
S
A
I
R
N
S
A
S
P
Q
V
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
V949
L
Q
H
L
R
T
V
V
G
S
E
L
G
Y
L
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
100
N.A.
80
N.A.
73.3
80
N.A.
N.A.
73.3
N.A.
66.6
N.A.
40
6.6
0
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
86.6
93.3
N.A.
N.A.
80
N.A.
73.3
N.A.
73.3
20
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
0
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
8
15
0
0
15
8
15
0
8
0
22
% A
% Cys:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
8
0
0
0
8
0
8
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
0
8
8
0
0
8
8
0
0
% G
% His:
0
58
8
0
0
0
8
0
8
0
0
0
0
0
0
% H
% Ile:
0
15
8
15
0
0
8
0
0
0
36
8
29
0
0
% I
% Lys:
0
0
65
58
50
0
43
0
0
15
0
0
0
0
0
% K
% Leu:
8
0
8
8
0
58
8
8
8
0
15
65
0
0
15
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
8
0
0
0
43
0
0
0
8
58
15
% P
% Gln:
50
8
0
0
8
0
0
0
0
50
0
8
0
22
0
% Q
% Arg:
8
0
0
0
8
8
15
36
8
0
15
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
0
15
0
22
8
15
8
8
0
% S
% Thr:
0
8
0
0
8
8
0
0
0
0
0
0
0
8
43
% T
% Val:
0
8
0
8
0
15
15
8
0
0
0
0
43
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _